Granulation Strategies And Technologies: Recent Progresses - PMC

Mix of powders containing pharmaceutical excipients and API may be compressed into tablets either by direct compression or after making granules by agglomeration or granulation techniques ( Fig. 1). The granulation technique could also be widely categorized in to 2 varieties, dry granulation and wet granulation, based on the type of methodology used to facilitate the agglomeration of powder particles ( Fig. 1). Dry granulation makes use of mechanical compression (slugs) or compaction (roller compaction) to facilitate the agglomeration of dry powder particles, while the wet granulation uses granulation liquid (binder/solvent) to facilitate the agglomeration by formation of wet mass by adhesion. Among these two methods, wet granulation is the most widespread granulation technique used despite the fact that it entails a number of unit processes corresponding to wet massing, drying and screening, that are complex, time consuming, and expensive requiring giant space and multiple gear.1,2,5

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- Principal stress system, pre-stress system, filling system, feeding system undertake modular design.- Simple construction. These modular components can be freely adjusted or removed. Non-interference between maintenance are easy.

- The main strain and pre-pressure are the identical construction which will be interchanged each other.

- Both main stress and pre-strain are all 100kn which make it simpler for forming tablets.